Zoology 476 Tentative Schedule Spring '00

Week

Reading

Lab

Jan 17

MLKD - No Lecture

19

Intro & overview of development

Ch. 1 (pp. 6-13)

microscope/early echinoderm devel

21

Question, methods, and model systems in developmental biology

Ch. 1 (pp. 13-19)

Jan 24

Cellular basis of development I - cell cycle, shape, and movement

Ch. 2 (pp. 20-30, 34-35)

26

Cellular basis of development II - the cell and its environment (cell membrane, junctions, signalling)

Ch. 2 (pp. 30-34, 38-42)

early amphib development I

28

Cleavage I - Yolk distribution and cleavage patterns

Ch. 5 (pp. 92-104)

QUIZ: early echinoderm devel.

31

Cleavage II - Control mechanisms

Ch. 5 (pp. 105-116)

Feb 2

Cell fate, potency, and determination I - Fate mapping and clonal analysis

Ch. 6 (pp. 117-122)

Early amphib devel II - fate mapping**

4

Cell Fate, potency, and determination II - Fate vs. potency (Roux vs. Driesch)

Ch. 6 (pp. 122-138)

QUIZ: early amphib development

Feb 7

Cloning and genomic equivalence

Ch. 7

9

Cytoplasmic determinants I - Classical examples

Ch. 8 (pp. 162-173)

4 mm tadpole

11

Cytoplasmic determinants II - Experimental analysis

Ch. 8 (pp. 173-183)

Feb 14

Axis formation

Ch. 9 (pp. 184-203)

16

Mesodermal induction in Xenopus

Ch. 9 (pp. 203-211)

Xenopus - axis formation**

18

Gastrulation I - sea urchins and amphioxus

Ch. 10 (pp. 213-222)

QUIZ: 4 mm tadpole

Week

Reading

Lab

Feb 21

Exam I (material through 2/16)

23

Gastrulation II - Xenopus and other amphibians

Ch. 10 (pp. 222-232)

(+ live chicks)

25

Gastrulation III - Birds and other amniotes

Ch. 10 (pp. 232-239)

28

Neurulation

Ch. 11 (pp. 240-249)

Mar 1

Neural induction and patterning

Ch. 11 (pp. 249-261)

48 hr chick

3

Ectodermal organs I - Neural tube

Ch. 12 (pp. 263-276)

QUIZ: 21-33 hr chick

Mar 6

Ectodermal organs II - Neural crest

Ch. 12 (pp. 276-283)

8

Ectodermal organs III - Placodes and Epidermis

Ch. 12 (pp. 283-290)

72 hr chick

10

Endodermal derivatives

Ch. 13 (pp. 291-300)

QUIZ: 48 hr chick

Mar 13

SPRING BREAK!

Mar 20

Axial and paraxial mesoderm

Ch. 13 (pp. 300-306)

22

Intermediate and lateral plate mesoderm, extraembryonic membranes

Ch. 13 (pp. 306-314, 316-319)

72 hr chick (cont.)

24

Epithelial-mesenchymal interactions: Limbs, lungs, teeth, and feathers

Ch. 13 (pp. 314-316)

Mar 27

Cell adhesion and morphogenesis

Ch. 25

29

ECM and morphogenesis

Ch. 26

10 mm pig

31

Pattern formation and embryonic fields

Ch. 20

QUIZ: 72 hr chick (20 pts)

Week

Reading

Lab

Apr 3

Developmental genetics - origin and methods

Ch. 14

5

Transcriptional control of development

Ch. 15

Planarian regeneration**

7

Pattern formation in Drosophila I - Overview and maternal genes

Ch. 21 (pp. 493-504)

Apr 10

Exam II (material through 3/31)

12

Pattern formation in Drosophila II - Segmentation genes

Ch. 21 (pp. 504-516)

10 mm pig (cont.)

14

Pattern formation in Drosophila III - Homeotic genes and dorsoventral patterning

Ch. 21 (pp. 516-528)

Apr 17

Genetic analysis of vertebrate development I - methods

Ch. 22 (pp. 542-547)

19

Hox genes and axial patterning in vertebrates

Ch. 22 (pp. 547-560)

Lab Practical

21

Sex determination - genetics and environment

Ch. 27 (pp. 660-670)

Apr 24

Sex differentiation - hormones

Ch. 23 (pp. 686-698)

26

Gametogenesis and the germ line I - Intro and spermatogenesis

Ch. 3 (pp. 43-54)

Drosophila devel.

28

Gametogenesis and the germ line II - Oogenesis

Ch. 3 (pp. 54-69)

May 1

Fertilization

Ch. 4

3

Development and Evolution I - classical topics

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Symposium on Development

5

Development and evolution II - molecular insights

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May 10

Final (10:20-12:10)