What the spouse and other family members should do about a patient with a tumor or lesion to the cerebellum By Brenna Kay Sjotvedt The cerebellum is responsible for motor coordination, balance, and there has been evidence recently that it is also involved in speech, and memory. Damage to the cerebellum can cause impairments to standing, walking, and the performance of other coordinated movements. The cerebellum also controls how smooth or jerky one's movements are, so damage can also cause a jerkiness of movements, and poorly coordinated and exaggerated movements. Depending on how severe the damage is, the afflicted person may not even be able to stand (Carlson, 2001). Recent studies have suggested that damage to the cerebellum can cause problems with speech, such as being unable to find words while speaking, difficulty comprehending the speech of others, and speech initiation disturbances (Marien, Engelborghs, Pickut & DeDeyn, 2000). Phonation and articulation can also be impaired and language expression is monotonous and slow, as well as difficult to understand (Fabbro, Moretti & Bava, 2000). These deficits are only occasional for those afflicted with cerebellar lesions. More frequent with cerebellar lesions is memory deficits. Procedural memory and verbal short-term memory are mostly affected. Damage to the cerebellum can cause problems during the processing and organization of sensory information, as well as the inability to remember things by rehearsal, because the cerebellum is reported to be involved in rehearsal (Silveri & Misciagna, 2000). The afflicted person may need help getting around because of a loss of balance, so it would be important to keep this in mind and have a family member or the patient's spouse around whenever possible. There may also be times when the patient may knock something over or spill something because of the jerkiness of their movements and it is important that the spouse and family members remember that this is not the patient's fault and hand things to the patient when possible. It is also important to remember that the patient is more than likely even more frustrated than the family is that s/he cannot do normally the things that s/he used to be able to do. Also, because of the speech problems, there may be times when the spouse and other family members of the patient will become impatient and annoyed. Again, it is important to remember that the patient is very frustrated as well. The speech may be slow and monotonous and the family may have a problem understanding what the patient is saying, as well as the patient not understanding what the person talking to him/her is saying. The family may also get frustrated with the patient when s/he cannot find the words to say what s/he wants to say. There is language therapy available for those that need it, and it is generally very helpful for those that get it. And because of the memory problems, the family may find that they have to repeat themselves often. Because the cerebellum seems to be involved in rehearsal of information, the patient may not be able to remember for long what is said to them, since they have a hard time keeping information in their short-term memory long enough. Also, since procedural memory is affected, the patient may no longer be able to drive, ride a bike, or do many of the other well practiced habits s/he was once able to do. (Keep in mind that even if the patient is able to perform those well practiced habits, chances are they are moving jerkily and that in itself my impair them from doing those things.) References Carlson, N. R. (2001). "Physiology of Behavior." (7th ed.). Massachusetts: Allyn and Bacon. Fabbro, F., Moretti, R., & Bava, A. (2000). "Language impairments in patients with cerebellar lesions." Journal of Neurolinguistics. Volume 13, Issues 2-3. 173-188. Marien, P., Engelborghs, S., Pickut, B. A., & DeDeyn, P. P. (2000). "Aphasia following cerebellar damage: fact or fallacy?" Journal of Neurolinguistics. Volume 13, Issues 2-3. 145-171. Silveri, M. C. & Misciagna, S. (2000). "Language, memory, and the cerebellum." Journal of Neurolinguistics. Volume 13, Issues 2-3. 129- 143. The Implications Damage to the Cerebellum has for Employers Kristi Shanoff Any type of brain damage will inevitably serve as an impairment to the one sustaining the damage. Damage to the cerebellum is no exception. Seeing as the cerebellum accounts for 11% of the brain's mass and is the second largest part of the brain (Marieb & Mallatt, 2001), it is not surprising that many aspects of human behavior are dependent upon a fully functioning cerebellum. Because of this, any damage to the cerebellum has significant implications, especially for an employer. The cerebellum is most commonly known as the part of the brain that coordinates body movements as well as maintain an individual's equilibrium and posture. In regards to movement, the cerebellum receives information regarding the movements being planned by the motor cerebral cortex. The cerebellum then processes the information, comparing it to what movements are actually occurring. Because of this, the feedback received from the cerebellum by the motor cerebral cortex allows movements to be corrected so that they may be well coordinated (Marieb & Mallatt, 2001). Because of this, when the cerebellum is damaged, walking and standing can become difficult tasks. Those with extensive cerebral damage aren't even able to stand. Plus, movements may become jerky, poorly coordinated, and/or overly exaggerated (Carlson, 2001). In addition to being partially responsible for movement, there is a significant amount of recently conducted research indicating that the cerebellum is involved with several other cognitive processes (Silveri & Misciagna, 2000), especially because it works in conjunction with several other parts of the brain (i.e. the reticular system, hypothalamus, limbic system, and associative/neocortical systems). Additionally, there's a growing amount of evidence suggesting that the cerebellum is also somewhat responsible for an individual's emotional health (Schmahmann, 2000). Because of this, depending on both where the cerebral damage occurs and what type of damage as sustained (i.e. lesion, tumor, cyst (Fabbro et al., 2000), cerebellar degenerative disease (Silveri & Misciagna, 2000) etc.), different behaviors will be affected (Fabbro et al., 2000). There are two cognitive processes the cerebellum has been found to be involved with. One of those cognitive processes is memory, specifically phonological short-term memory. Phonological short-term memory is also referred to working memory (Fabbro et al., 2000). It's responsible for the retention of verbal information for short periods of time as well as for the rehearsal system. In regards to procedural learning, the cerebellum is specifically involved with motor adaptation, as demonstrated by subjects who had sustained cerebral damage whose motor adaptation was not as good as those who hadn't sustained cerebral damage. Motor adaptation refers to as "a modification in motor performance that does not violate the speed- accuracy trade-off" (Silveri & Misciagna, 2000). The fact that the cerebellum is directly involved with phonological short-term memory (which is responsible for word repetition, sentence comprehension, and new language acquisition) has important implications for language, the other cognitive process the cerebellum has been found to be involved with (Silveri & Misciagna, 2000). There are several aspects to the effects cerebral damage can have on language, particularly in speech production. These aspects include the following: acceleration of orofacial gestures (referring to how quickly the mouth is able to move during speech production); timing and coordination of complex articulatory sequences (Ackermann & Hertrich, 2000); word fluency and verb production (This is referring to a study done in which subjects who had sustained damage to the right cerebral hemisphere were required to generate verbs in response to nouns (Petersen et al. as cited in Silveri & Misciagna, 2000)); and sentence construction, particularly grammar (Silveri & Misciagna, 2000). Additionally, cerebral damage does not only affect an individual's speech production, but studies indicate that cerebral damage can also affect an individual's verbal comprehension abilities (Fabbro et al., 2000). Because speech production is effected in so many ways by damage to the cerebellum, an individual who sustains damage to the cerebellum often exhibits both ataxic dysarthria and mutism. Symptoms of ataxic dysarthria include slurred speech, alteration of timing patterns (Silveri & Misciagna, 2000), distorted consonant and vowel productions, and a slowed speaking rate (Ackermann & Hertrich, 2000). Mutism refers to "impairment of word selection and fluency and syntactic disorders in sentence production" (Silveri & Misciagna, 2000). In addition to ataxic dysarthria and mutism, individuals suffering from cerebral damage also tend to speak nasally as well as pronounce consonants in an "explosive" manner, suggesting that cerebral damage affects phonation (the vocalization of sounds) more than articulation in speech production (Fabbro et al., 2000). Lastly, it has been recently postulated that damage to the cerebellum has a direct influence on emotional health. This postulation has been supported by numerous case studies. In one case, a group of people had electrodes implanted into the cerebellum in order to help reduce the occurrence of epileptic seizures. In addition to seizure reduction, the group reported improvements in aggression, anxiety, and depression (Riklan et al. as cited in Schmahmann, 2000). (However, it should be noted that those improvements in health could also be because of the reduction in seizures.) In another case study, 11 patients who were institutionalized for emotional dyscontrol had electrodes implanted in a particular region of the cerebellum. After their surgeries, they exhibited "extraordinary" improvements. Because of the extent of their improvements, they were allowed to be "released to the community and live essentially normal lives." In addition to these case studies, there's evidence that damage to the cerebellum can influence the occurrence of the following emotional disorders because of the cerebellum's association with all the different parts of the brain: schizophrenia; depression, specifically bipolar disorder; and autism in children (Schmahmann, 2000). As can be seen, damage to the cerebellum can manifest itself in many different ways, and each manifestation poses a unique challenge for the individual affected. It is likely that these challenges can be overwhelming at times as well as relative incapacitating to the individual. Undoubtedly, an individual who has sustained some type of cerebral damage will have a harder time functioning as a successful citizen in today's society, especially when it comes to seeking employment. (It should be noted, though, that there is hope for these individuals because of the seemingly rapid recovery rate in individuals who have undergone surgery in order to correct the cerebral damage they've sustained (Fabbro et al., 2000).) Employers working with an individual who has sustained cerebral damage have to keep several things in mind. First of all, the speech problems individuals with cerebral damage experience could cause significant complications which could frustrate employers. This is because communication could potentially be extremely difficult; not only could the individual with cerebral damage have a hard time speaking in a way which is understandable, but the individual may also have a hard time comprehending what the employer. In the case of the employer, not being able to understand what the employee is saying combined with not being able describe to the employee successfully the tasks that the employee is expected to perform would cause significant frustration. The employer would probably give the employee tasks requiring little verbal communication as well as explanation. Although this seems like a satisfactory solution, this could prove frustrating for the disabled employee. Despite all the communication deficits cerebral damage causes, the affected individual's IQ is not any lower than others'. Thus, the affected individual is just as smart as anyone else, but has trouble proving it (Fabbro et al., 2000). The motor impairments experienced by individuals who've sustained cerebral damage also poses a significant challenge in an employment setting. Most jobs require at least good control over fine motor skills. However, those with cerebral damage (even if the damage isn't that extensive) have often lost the ability to execute fine motor movements smoothly (Carlson, 2001). This means that the impaired individual would have to have a task requiring little motor skills in order to keep his/her job. For an employer, this means having an employee with very little versatility. Most the time, such an employee is either never hired or when hired, doesn't have the opportunities to advance. Lastly, the emotional problems those with cerebral damage face would also cause them problems in a job setting. One set of reported mood alterations in 26 children with cerebral damage were the following: an increase in aggression; an increase in irritability; the tendency to avoid physical and eye contact; and a decreased ability to tolerate the company of others (Schmahmann, 2000). Although these symptoms were recorded in children, this doesn't mean that the same symptoms couldn't appear in adults who have sustained the same amount of cerebral damage. Any adult exhibiting any of the characteristics described above would be a difficult person to work with, let alone be around. This would make it hard for employers. Nobody wants an employee who's going to tell off customers or avoid any sort of contact with his coworkers. Because of this, the only types of jobs available for people exhibiting characteristics above are the low-paying, solitary, menial jobs that no one else wants. This is unfortunate for the impaired individual; not only is the impaired individual's intelligence undermined in such jobs, but because the individual is more likely to be depressed because of the fact that he/she is overqualified for the job (Johnson & Johnson, 1996), the impaired individual will in turn be more likely to exhibit the emotional characteristics that earned him/her the menial job in the first place. As can be seen, with the emotional, physical, and cognitive impairments combined, those sustaining cerebral damage have a tough road to travel. Luckily, as mentioned before, those who are able to undergo surgery to repair the damage they've received experience a relatively thorough recovery (Fabbro et al., 2000) (Schmahmann, 2000). However, this does not help those who are unable to undergo such a surgery. Hopefully, with the ever-increasing amount of improvements being made within the sciences, cerebral damage will become fully understood and curable, thus making the lives of those impaired and those faced with attempting to employ the impaired more livable. References Ackermann, H., Hertrich, I. (2000). The contribution of the cerebellum to speech processing. The Journal of Neurolinguistics, 13(2-3), 95-116. Amato, C.J. (1998). The World's Easiest Guide to Using the APA: A User-Friendly Manual for Formatting Research Papers According to the American Psychological Association Style Guide (2nd ed.). Westminster: Stargazer Publishing Company. Carlson, N.R. (2001). Physiology of Behavior. (7th ed.) Boston: Allyn and Bacon. Fabbro, F., Moretti, R., Bava, A. (2000). Language impairments in patients with cerebellar lesions. Journal of Neurolinguistics, 13(2-3), 173-188. Johnson, G.J., Johnson, W.R. (1996). Perceived over qualification and psychological well-being. The Journal of Social Psychology, 136(4), 435-445. Marieb, E.N., Mallatt, J. (2001). Human Anatomy. (3rd Ed.) San Francisco: Benjamin Cummings. Schmahmann, J.D. (2000). The role of the cerebellum in affect and psychosis. Journal of Neurolinguistics, 13(2-3), 189-214. Silveri, M.C., Misciagna, S. (2000). Language, memory, and cerebellum. Journal of Neurolinguistics, 13(2-3), 129-143. Lesions in the cerebellum The Neuropsychologist Annie Topolewski The cerebellum, known as the "little brain" is made up of the two smaller hemispheres located at the back of the cerebrum. The cerebellum plays an important role in the coordination of voluntary movements by fine-tuning commands from the motor cortex in the cerebrum. All motor activity, from hitting a golf ball to playing a musical instrument, is dependent on the cerebellum (Encarta, 1999). Lesions to the cerebellum can cause problems with standing, walking, and performance of coordinated movements. The movements become jerky and erratic. The symptoms from lesions in the cerebellum change depending on what part of the cerebellum is damaged. For example, if the vermis is damaged there may be disturbances in posture and balance, while damage to the intermediate zone can cause limb rigidity (Carlson, 1998). An evaluation by a neuropsychologist can be critical in determining if there is some sort of brain injury, and if there is injury, which brain functions are impaired and which remain intact. The neuropsychologist is also involved in monitoring recovery and determining the effectiveness of the rehabilitation (www.neuropsychologycentral.com). When there is any change in behavior following some sort of brain injury that effects memory, learning, or the ability to function, it is important for the patient to seek a neuropsychological evaluation. However, the patient should first rule out any medical causes of the symptoms prior to seeing the neuropsychologist (www.neuropsychologycentral.com). The neuropsychologist may have some sort of behavior checklist that they use. One such list, the neuropsychological interview form, requires much detail about the physical functioning of the patient. The interview form requests information on vision, hearing, touch, smell, taste, pain, balance, motor abilities, walking, memory, speech, and attention, among many other areas. The neuropsychologist will examine the patient, checking for signs of brain injury. A blow to the head may result in headache, dizziness, paralysis, convulsion, or temporary blindness, depending on the area of the brain affected. It is the job of the neuropsychologist doing the examination to determine which area of the brain has been damaged based on the symptoms that the patient presents with. Since the cerebellum helps to coordinate movement, a patient with a lesion in the cerebellum may stumble, have an irregular gait, or have difficulties writing (Wickelgren, 1998). The patient may present with dysmetria, which is when the limb may undershoot, or hypermetria, when the limb overshoots an intended target. Speech can also be affected. Damage to the cerebellum can cause abnormal transitions from consonants to vowels, slower speech, and reduced speech movement acceleration (Schulz, 1999). The neuropsychologist will test the patient's coordination by asking them to touch their finger to their nose, and also by using the heel-to-shin test. They also check the patient for clumsiness and slowness. They are looking for changes in behavior. There are numerous other motor signs of damage, such as, rigidity, ballism, dystonia, akinesia, tremor, and chorea, which is characterized by involuntary, purposeless, spasmodic movements of the entire body. Spasticity is reduced movement due to stiffness of the muscles and exaggerated reflexes. Ataxia is loss or impairment of muscular coordination, characterized by involuntary trembling of parts of the body when performing voluntary movements, difficulty in performing precise movements, and disturbance in balancing the body (Cytowic, 1996). Lalonde and Marquard (2000) found that patients with damage to the cerebellum show some impairment in test of visuospatial organization, selective attention, working memory, frontal lobe- sensitive behaviors and associative learning. They used a variety of existing measures to test for impairment in these areas. For example, to test visuospatial organization they used block design and object assembly subtest of the Wechsler's Adult Intelligence Scale and the Raven Standard Progressive Matrices. In measuring short-term or working memory they used the digit span subtest of the Wechsler Adult Intelligence Scale. The prognosis for recovery is dependent on many factors. "Of stroke survivors, 70-80% will have mild or no functional deficit, 20% will be moderately disabled, and fewer than 10% will be severely disabled"(Anderson, 1994). References: Anderson, R.M. (1994). Practitioner's guide to clinical neuropsychology. New York: Plenum press. Carlson, N.R. (1998). Physiology of Behavior. Boston: Allyn and Bacon. Cytowic, R.E. (1996). The neurological side of Neuropsychology. Cambridge, Mass.: The MIT press. Encarta Encyclopedia. (1999). Redmond, Washington: Microsoft. Lalonde, R. and Botez-Marquard, T. (2000). Neuropsychological deficits of patients with chronic or acute cerebellar lesions. Journal of Neurolinguistics, 13, 117-128. Schulz, G.M. and Dingwall, W.O. (1999). Speech and oral motor learning in individuals with cerebellar atropy. Journal of Speech, Language and Hearing Research, 42, 1157-1176. Wickelgren, I. (1998). The cerebellum: The brain's engine of agility. Science, 281, 1588-1591. www.neuropsychologycentral.com Waridi Parsons Psych 321 May 4,2001 About a week ago, I began to feel a ringing kinda buzzing sound in my ear. I also felt dizzy for no reason at all. I decided to go in to the doctor to see what was wrong. I did not know what to expect nothing like this had ever happened to me. I remember my Uncle Tory died a few years before from a brain tumor. My uncle got sick he waited a while until he got help. He began to experience headaches, vomiting. The fluid in his brain was unable to circulate which caused Increased Interacranial Pressure. The doctors told me then that I should be aware of these symptoms if they ever occurred. The next week I had an appointment with Dr. Parsons and she explained that she was going to give me a neurological examination. I wasn't sure what the exam was about, but she assured me that it would not hurt. NEUROLOGICAL EXAMINATION A basic neurological examination includes the following: Eye movement, pupil reaction, and eye reflex tests. Hearing tests using a ticking watch or tuning fork. Reflex tests using a rubber hammer. Balance and coordination tests. Heel-to-toe walking. Heel-to-shin movements. Balance with feet together and eyes closed. Rapid alternating movements such as touching the finger to the nose with eyes closed. Sense of touch tests using a pinpoint and cotton ball. Sense of smell tests using various odors. Facial muscle tests--smiling, grimacing. Tongue movement, gag reflex tests. Head movement tests. Mental status tests. Asking for the current time and date. Asking who is President. Abstract thinking test. Asking for the meaning of "a stitch in time saves nine. "Memory tests. Asking to have a list of objects repeated. Asking for a description of the food eaten at breakfast yesterday. Asking for a description of the events of last Thanksgiving. A few days after the examination Dr. Parsons called to set up a follow-up appointment. She said I needed more tests, maybe a CAT scan (Computerized Axial Tomography). Dr. Parsons explained that a CAT scan would be able to see past the bone in my brain. She explained that I would get an injection of a special dye to detect the abnormal tissue that may be in my brain. About two weeks after the Cat scan test came back. The doctors were sure that they had found a malignant brain tumor. The doctors explained to me that because my tumor was malignant it was life- threatening. The exact location of the cancer was in my cerebellum, the doctor told me that it was a small mass and that I had to have surgery. I decided to do some investigations and find out just what was going on in my brain. First I wanted to know what was my cerebellum and what it did. I found that the cerebellum receives visual, auditory, vastibular, and somatosensory information. It is the most important part of the motor system. It also receives information about individual muscle movements being directed by the brain. If my cancer was not treated I would eventually began to experience symptoms. These symptoms would include jerky, poorly coordinated, exaggerated movements. I learned that the cerebral area of my brain was very important and that this surgery was serious. The doctor told me that Surgery is the treatment of choice for accessible brain tumors. Accessible tumors are those which can be surgically removed without causing severe neurological damage. Tumors located in gray matter or deep within the brain may be inaccessible. I knew I needed this surgery because without in I might not be able to walk someday if the cancer started to spread. I just wanted to get rid of the cancer at one time. I knew that the surrey was not the end of the road I still might have to have additional treatments if the cancer was not completely removed. Even if it were completely removed I still would have to be careful to make sure it never comes back. The goal of surgery was to remove all visible tumor. Many benign tumors are treated only by surgery. Most malignant tumors require additional treatment. Malignant tumors lack distinct borders. They often invade nearby normal brain tissue. Tumor cells may also spread throughout the brain and spine by way of the cerebrospinal fluid. But, even partial tumor removal is beneficial. The purpose of surgery is: To remove as much tumor as possible. Partial removal (debulking) of a tumor provides relief of symptoms, improved quality of life, and a smaller tumor burden for other treatment modalities. To help establish an exact diagnosis removal of a sample of tumor to be examined under a microscope in the laboratory provides an exact diagnosis to determine the extent of the tumor. The neurosurgeon sees the actual tumor in the brain to provide access for other treatments, such as newer forms of radiation during surgery, implants may be placed or radiation may be delivered. After this ordeal was over the cancer was removed and I had a couple of sessions with the Chemotherapy and I have not seen the cancer since. References Carlson, N. R. (2001). "Physiology of Behavior." (7th ed.). Massachusetts: Allyn and Bacon.Return to the Project Table of Contents
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