Chem 431 Lecture Notes, Fall 2007
These are the notes
I use to present my lectures. They are here for the convenience
of my students. They are unedited and thus liable to error. The
expansions and corrections I put in during my lectures are not
included. If you find errors in these notes, please inform me
ASAP via e-mail: rap1 @
axe.humboldt.edu
- Lecture 1; 20 August: Introduction;
What is Biochemistry? Characteristics of Life.
-
Lecture 2; 22 August: Characteristics of Life, cont.; Cells and Organelles.
- Lecture 3; 24 August: Cells and Organelles, cont.; The Elements of Life.
- Lecture 4; 27 August: Biomolecules; Origin of Life.
- Lecture 5; 29 August: Early Evolution of Life; Introduction to Water.
- Lecture 6; 31 August: Water Properties. Water Ionization.
- Lecture 7; 5 September: pH & Buffers; Amino Acids 1.
- Lecture 8; 12 September: Amino Acids 2; Peptides and Amino Acid Chemistry.
- Lecture 9; 14 September: Peptides, cont.; 3-D Protein Structure 1, Overview of Primary to Quaternary Structures.
- Lecture 10; 17 September: Protein Structure 2, Secondary and Supersecondary (motif) structures.
- Lecture 11; 19 September: Protein Structure 3, Supersecondary (motif) structures and Protein Classification. Added X-ray diffraction notes 9/21/07
- Lecture 12; 21 September: Protein Structure 4, Domains and Quaternary Structures; Protein Folding.
- Lecture 13; 24 September: Protein Folding, cont., Stages of Folding, Chaperones; Protein Dynamics.
- Lecture 14; 26 September: Myoglobin and Hemoglobin as Example Proteins;Oxygen Binding Behavior.
- Lecture 15; 28 September: Enzymes - Specificity; Introduction to Enzyme Kinetics.
- Lecture 16; 1 October: Enzyme Kinetics, cont.: Enzyme Inhibition.
- Lecture 17; 3 October: Enzyme Kinetics, cont.: Multi-substrate Enzymes; Rate Effects of Temperature and pH; Introduction to Mechanisms of Enzyme Catalysis.
- Lecture 18; 8 October: Mechanisms of Enzyme Catalysis, cont. - Mechanisms of Chemical Catalysis; Lysozyme Mechanism Model.
- Lecture 19; 10 October: Mechanisms of Enzyme Catalysis, cont. - Chymotrypsin Mechanism Model; Carbohydrates, Monosaccharides, etc. Disaccharides.
- Lecture 20; 12 October: Carbohydrates, cont., Disaccharides, cont.; Polysaccharides.
- Lecture 21; 15 October: Structural Polysaccharides, cont.; Lipids; Lipid Bilayers & Biological Membranes.
- Lecture 22; 17 October: Biological Membranes, cont.- Membrane Proteins.
updated 10/19
- Lecture 23; 19 October: Membrane Protein Targeting; Introduction to Vitamins and Cofactors.
- Lecture 24; 22 October: Introduction to Vitamins and Cofactors, cont.
- Lecture 25; 24 October: Introduction to Metabolism; High-Energy Compounds.
- Lecture 26; 26 October: Thermodynamics in Metabolism; Introduction to Carbohydrate Metabolism, Glycolysis 1.
- Lecture 27; 29 October: Glycolysis 2 - Thermodynamic Aspects, HK-PFK Reactions.
- Lecture 28; 31 October: Glycolysis 3 - Regulation of PFK; Aldolase to PGA Kinase.
- Lecture 29; 2 November: Glycolysis 4 - PGA Mutase to Pyryvate Kinase; Lactate Dehydrogenase.
- Lecture 30; 5 November: Gluconeogenesis; Pyruvate DH; Introduction to the Kreb's Cycle. corrections posted 11/7
- Lecture 31; 7 November: Reactions of the Kreb's Cycle; TCA Cycle Control; Aerobic Glucose Metabolism.
- Lecture 32; 9 November: Kreb's Cycle Intermediate Conversion and Filling the Cycle (Anapleurosis); Kreb's Cycle Intermediate Metabolism; Aerobic Glucose Control; Metabolism of Other Sugars.
- Lecture 33; 14 November: Glycogen Metabolism and Control.
- Lecture 34; 26 November: The Pentose Phosphate Shunt for Glucose Oxidation - Producing Reducing Equivalents for Reductive Anabolism.
- Lecture 35; 28 November: The beta-Oxidation of Fatty Acids.
- Lecture 36; 28 November: The beta-Oxidation of Fatty Acids - Energy Calculations; Oxidation of Unsaturated and Odd-Chain Fatty Acids; Ketone Bodies.
- Lecture 37; 3 December: Ketone Body Metabolism; Mitochondria; Energy & Reduction Potentials; The Electron Transport System.
- Lecture 38; 3 December: The Electron Transport System, cont.
- Lecture 39; 3 December: Last Lecture. Oxidative Phosphorylation; Mitochondrial Cross-membrane Exchange Systems.
Last modified 7 December 2007
Pathway Diagrams