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Brendan Kelly, Ph.D.

Lab Coordinator - Humboldt CIRM Shared Resources Laboratory

Brendan received his B.S. and M.S. in Biology from Humboldt State University. After initially training in marine biology, he transitioned into regenerative medicine via a CIRM Bridges Fellowship, focusing on the development of human induced pluripotent stem cell (iPSC) models. He earned his Ph.D. from Cardiff University, where he used cell reprogramming and genome editing to investigate the molecular basis of lysosomal dysfunction in Huntington’s Disease. Brendan has since held postdoctoral positions at the UK Dementia Research Institute and Cardiff University’s Brain Repair Group, specializing in the use of neuronal models to study the pathomechanisms of Alzheimer’s, Parkinson’s, and Huntington’s. His background also includes experience in the biotech industry as the first employee of an iPSC manufacturing startup. In addition to his research, Brendan is a Cardiff University Education Associate Fellow and has extensive experience mentoring students in advanced laboratory techniques.

Areas of Interest

My professional interests center on the generation and application of isogenic, iPSC-derived models to investigate the molecular pathomechanisms of neurodegenerative and neurodevelopmental diseases. I specialize in utilizing genome editing and advanced imaging to characterize cellular pathology and disease progression in human-derived neurons. In my current role, I leverage this expertise to facilitate regenerative medicine research for others, providing the technical support and training necessary to make complex stem cell technologies accessible to the broader scientific community.

  • B.S. (2010) Humboldt State University, Biology - Marine Emphasis
  • M.S. (2014) Humboldt State University, Biology
  • Ph.D. (2023) Cardiff University, Biology

Differences in white matter detected by ex vivo 9.4T MRI associated with axonal changes in Huntington's Disease, Neurobiology of Disease, 2026.

Pluripotent stem cell manufacturing system and method for producing induced pluripotent stem cells. U.S. Patent No. 11,286,454 (Granted 2022). Inventors: Tanabe, K., Kelly, B. P., Suto, K.

Detrimental effect of zwitterionic buffers on lysosomal homeostasis in cell lines and iPSC-derived neurons, Journal of Cell Science, 2020.