CSF1R Inhibition Restores Cognition Following Immunotherapy

Presentation Year

2022

College or Department

College of Natural Resources & Sciences

Short Description of your Research or Creative Project (700 characters or less)

Patients that undergo CAR T-cell therapy often experience significant side effects, including cognitive decline. We have found that CAR T-cell therapy increases microglial activation and disrupts the myelin sheath that is necessary for saltatory conduction. We seek to understand the long term neurological effects of CAR T-cell therapy and ways to restore cognition in patients undergoing immunotherapy.

Permission to Publish Work

Yes