Mathematical Modeling of Tumor and T-Cell Dynamics

Presentation Year

2020

College or Department

College of Natural Resources & Sciences

Short Description of your Research or Creative Project (700 characters or less)

We propose and analyze a mathematical model for the interaction of T cells and tumor cells using a system of ordinary differential equations with the goal of understanding immune-mediated tumor rejection. We explore parameter sets which yield qualitatively different behavior. A major goal of this work is the determination of parameters which play a critical role in remission or clearance of the cancer in the model. In addition to our ODE model, we present an agent-based model to illustrate how naïve T cells are primed in the lymph node to fight cancer. This priming involves antigen presentation, cytokine signaling, and chemotaxis.

Permission to Publish Work

No