Presentation Year

2022

Depreciated Participant

Joshua Chapman Chemistry Undergraduate Student, Parker Chapman Chemistry Undergraduate Student, Vini Buttino Chemistry Undergraduate Student

College or Department

Short Description of your Research or Creative Project (700 characters or less)

We wish to answer whether or not nanodiscs make an effective means of transporting medication, specifically in the treatment of fungal infections, seeing as research is currently examining its effectiveness in the transport of chemotherapy drugs to prevent collateral cell death. We tested nanodisc transport of the antifungal terbinafine, which is often used as a topical ointment for direct application, to determine if naondiscs improve its effectiveness as a fungal killer. We treated cultured samples of Brewer's yeast (Saccharomyces cerevisiae) with DMPC lipid nanodiscs wrapped in Apo-A1 protein and loaded with terbinafine and observed fungal cell death, as compared to direct application.

Permission to Publish Work

Yes

Node ID

1082

Page Classification