Reducing polyamine levels favors osteogenic differentiation of MSCs

Presentation Year

2022

College or Department

College of Natural Resources & Sciences

Short Description of your Research or Creative Project (700 characters or less)

Snyder-Robinson Syndrome (SRS) is a disorder that is characterized by severe osteoporosis. SRS is caused by a mutated gene coding for Spermine Synthase (SMS). SMS converts spermidine into spermine. Therefore SRS patients show increased spermidine/spermine ratios. Using bone marrow-derived Multipotent Stromal Cells, we found that supplementation with spermidine inhibits differentiation. During osteogenic differentiation the polyamine catabolic enzyme Spermidine/Spermine Acetyltransferase (SAT1) is upregulated. Also, inhibition of polyamine synthesis directly promotes osteogenesis. Therefore our results in vitro suggest that reduction of polyamines is necessary for osteogenic differentiation.

Permission to Publish Work

Yes