Agent-based Modeling of Microglia Behavior in the Context of Alzheimer's Disease

Presentation Year

2024

College or Department

College of Natural Resources & Sciences

Short Description of your Research or Creative Project (700 characters or less)

Our research investigates the role of microglia, the resident immune cells of the central nervous system (CNS), in the progression of Alzheimer's Disease (AD) using an agent-based model (ABM). Microglia cells, which typically act almost as neuronal guardians in the CNS can, under certain conditions, inadvertently contribute to AD progression if they become dysfunctional. By simulating microglia, neurons, and their interactions with signaling proteins, our ABM sheds light on the complex dynamics underlying the progression of AD, and has a the potential to inform therapeutic targets in AD treatment down the line.

Permission to Publish Work

Yes

Primary Contact: First Name

Emmanuel

Primary Contact: Last Name

Mezzulo

Primary Contact: Email

erm104@humboldt.edu

Primary Contact: I am a

Undergraduate Student

Primary Contact: Phone Number

7073322895