Investigating How LGL1 Loss Affects the Murine Brain Cytoarchitecture

Presentation Year

2024

College or Department

College of Natural Resources & Sciences

Short Description of your Research or Creative Project (700 characters or less)

Lethal (2) giant larvae 1 (Lgl1) maintains cell polarity and regulates cell migration. Its dysregulation is linked to gliomas, suggesting a role in tumor development. Glioblastomas may originate from neural stem/progenitor cells (NSPCs) accumulating mutations. Loss of Lgl1 in NPCs leads to cancer-like traits, including increased migration and altered signaling. Scanning electron microscopy can reveal morphological changes. This study compares WT and Lgl1 KO murine brain tissue, aiming to uncover changes associated with Lgl1 loss, offering insights into gliomagenesis.

Permission to Publish Work

Yes

Primary Contact: First Name

Madison

Primary Contact: Last Name

Gutierrez

Primary Contact: Email

mg595@hmuboldt.edu

Primary Contact: I am a

Graduate Student

Primary Contact: Phone Number

(909)2587417