Lineage Tracing of HoxB5 Cells of the Yolk Sac and their Contribution to the Adult Hematopoietic System

Presentation Year

2022

College or Department

College of Arts, Humanities & Social Sciences

Short Description of your Research or Creative Project (700 characters or less)

Understanding the origins of hematopoietic stem cells has been a challenge due to the lack of a marker specific to this cell type. Recently, our lab has functionally proven that HoxB5 is a unique marker for long-term HSCs in adult murine models. Whether HoxB5 is also a marker for HSCs in development, has not been studied. Here, we are labeling HoxB5+ cells found in the yolk sac blood islands at E7.5 by using a genetic tool we generated. We will then analyze all marked cells at several time points during development and adulthood. This project will discover if HoxB5+ cells from the yolk sac contribute to the adult hematopoietic system and the LT-HSC pool.

Permission to Publish Work

Yes