Breadcrumb
Understanding Microglial Phenotype Switching Through Dimensionality Reduction and Clustering Analysis
Presentation Year
2026
Undergraduate Student
Mathematics & Data Science
College or Department
College of Natural Resources & Sciences
Short Description of your Research or Creative Project (700 characters or less)
Microglia are the brain’s resident immune cells, capable of shifting between pro- and anti-inflammatory states to regulate neural homeostasis. Disruptions to this balance contribute to neurodegenerative diseases such as Alzheimer’s disease. We analyzed single-cell gene expression data from approximately 600 mouse-derived microglia across six weeks to identify genes that capture cellular variability in both high and low dimensional representations. We also performed unsupervised clustering to identify subpopulations within the dataset based on gene expression patterns. This allowed us to map the known spectrum of functional states these cells occupy and examine how these transcriptional states change over time.
Permission to Publish Work
Yes
Presentation File Upload
Primary Contact: First Name
Anthony
Primary Contact: Last Name
Wolfe
Primary Contact: Email
aw399@humboldt.edu
Primary Contact: I am a
Undergraduate Student
Primary Contact: Phone Number
5623887458
Indicate File Dimensions
4'x3'