ENGINEERING ENDOTHELIAL CELLS FOR THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION

Due to the theory that pulmonary arterial hypertension is a disease that is associated with damage to the function of the endothelium, overexpression of key enzymes and growth factors that give rise to a healthy endothelium, may prove to be a good method of treatment. Editing and engrafting endothelial cells onto stents and implanting them into arteries has shown to be a promising approach to treating pulmonary hypotension. Here, we show that using an AAV mediated approach to editing endothelial cells increases the population of GFP+ endothelial cells.