Lower back pain is the leading cause of disability and activity limitation worldwide. Previous research has indicated an association to lower back pain and fibrocartilage degeneration of the intervertebral disc (IVD). This degeneration is inevitable and occurs over time through daily strain from daily activities such as bending, lifting, and walking. Currently there is no treatment that effectively reverses fibrocartilage damage to the IVD. Previous research has used heterogeneous mixtures isolated from bone marrow or adipose tissue.

Improving the Clinical Efficacy of Mesenchymal Stromal Cells

Increasing the yield of extracellular vesicles secreted from placental-derived mesenchymal stromal cells

Expanding iPSCs for Clinical Applications

Characterizing the role of Lgl1 in Neural Stem Cells

Unbiased lineage tracing of long-term HSCs in vivo at steady-state

Characterization of Patient-Derived Huntington’s Disease Cells for Assessment of Therapeutic Efficacy

Defining the Transcriptomic Profile of Suitable Fibroblasts to Support the Pacemaking Phenotype in hiPSC-Derived Cardiomyocytes

Examining the function of Notch1 and Dach1 on collateral artery formation in the mouse brain through CRISPR-mediated inhibition and activation.

Mapping the Cellular Origins of Atherosclerotic Plaque